The user may use powerful Ultra Weapons after reaching Level Ultra, following the completion of experience levels up to Level 9. Weapons utilise different ammo types, with there being bullet, energy, shell, bolt, explosive and melee weapons. The weapons available to the player get increasingly advanced and powerful as the enemies become increasingly difficult and numerous. The player can have two weapons equipped at any time, such as a shovel and an assault rifle.
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The player starts with the basic revolver, but they may upgrade by taking weapons from red chests and collect more ammunition by opening yellow chests. As well as the available mutations being randomly generated, the levels themselves are procedurally generated, with every playthrough having a unique set of levels for the user to complete. Upon mutating 10 times the player can choose a character-specific "ultra-mutation". The game has a leveling system, where the player gains experience in the form of radiation pellets, or "rads", dropped by enemies, that allow them to get different mutations and choose what would benefit the character the most out of a selection of four, randomly selected mutations. Except for special weapons acquired in a hidden level and "crowns" retained until after defeating the final boss, anything acquired in one play-through does not carry over to the next. The user may continue looping indefinitely until death. After this, the player may choose to loop to the beginning of the game again with a greatly increased difficulty. The player progresses through the linear level structure until level 7-3, where the final boss, the Nuclear Throne, has to be defeated. Secondary sprites or skins can also be acquired for the characters played, if the player completes special or secret tasks. These abilities offered by the game for each individual character allow different play-styles to be achieved by the player and improve the variety and replay-value of the game. Each character has an ability unique to them, adding an additional element to the gameplay. Two additional secret characters can only be played under special circumstances during play. The player controls one of a total of 12 characters, 10 of which must be unlocked through play. There are daily and weekly challenge modes, allowing the user to compete against other players via the Steam platform for the best score (determined by the number of kills in the playthrough), on the same set of randomly generated levels. The game consists of two main game modes: single-player, and a local cooperative gameplay mode. Nuclear Throne is a top-down shooter roguelike game. Nuclear Throne was released on December 5, 2015, for Microsoft Windows, OS X, Linux, PlayStation 4 PlayStation Vita, and Nintendo Switch platforms, with an Xbox One release due in the future. Early prototypes of the game were distributed through Steam's early access program in 2013. Nuclear Throne is a top-down shooter roguelike video game by Vlambeer.